Yintoni iHarmine?

Ukudibanisa yi-beta-carboline kunye ne-harmala alkaloid. Kwenzeka kwizityalo ezahlukeneyo, ingakumbi isililo saseSyria kunye neBanisteriopsis caapi. I-Harmine ibuyisela umva i-monoamine oxidase A (MAO-A), iprotheyini eyahlula i-monoamines, iyenza i-Reversible inhibitor ye-monoamine oxidase A (RIMA). Ukudibanisa ayicinezeli i-MAO-B. IHarmine ngenye indlela ibizwa ngokuba yi-banisterin, banisterine, telopathin, telepathine, leucoharmine[5] kunye neyagin, yageine.

Ngaphezulu kweminyaka engama-20 yamava ndifunda kwaye ndivelisa i-harmine kwinkampani yam, ndingathanda ukubonelela ngenkcazo enzulu yale khompawundi inika umdla, iziphumo zayo, kunye nokusetyenziswa ngokufanelekileyo. Njengogunyaziwe kwintsimi, ndiya kuchaza iindlela ze-harmine zokwenza, iinzuzo ezinokuthi zibekho, iziphumo ebezingalindelekanga, kunye nolawulo olukhuselekileyo olusekwe kuphando lwamva nje.

I-Harmine Effects

IHarmine yialkaloid yengqondo efumaneka kwizityalo ezithile, ngakumbi isihlahla esikuMbindi Mpuma iPeganum harmala, eyaziwa njengeSyrian Rue. Isetyenziswe iinkulungwane kumalungiselelo amasiko kunye namayeza ngamasiko emveli. Namhlanje, i-harmine iyaqhubeka nokuphandwa ngemiphumo yayo ephawulekayo kwinkqubo ye-nervous central.

Imisebenzi ebalulekileyo ye-pharmacological ye enzakalisayo ivela kwisenzo sayo njenge-reversible inhibitor ye-monoamine oxidase A (MAO-A). Le catalyst yahlula i-monoamine synapses njenge-serotonin, i-melatonin, i-dopamine, i-norepinephrine, kwaye ilandele i-amines. Ngokuvala okwethutyana i-MAO-A, i-harmine igcina amanqanaba aphezulu ezi neurotransmitters, ekhokelela kwiziphumo zengqondo.

Ngokukodwa, ukonyuka kwe-serotonin kukholelwa ukuba negalelo kwiimpawu zokuchasa uxinzelelo xa zisetyenziswa kwiidosi ezithile. Uphando lukwabonisa ukuba lunokuthi luphilise i-neurogenesis ngokuxhasa amanqanaba e-BDNF kwihippocampus. Ngaphandle kokuphucula imvakalelo, ezinye izifundo zibonisa iingenelo ezinokubakho ekusebenzeni kwengqondo, njengokuphucula inkumbulo yokusebenza.

Kwiidosi eziphezulu, i-harmine ineempembelelo ze-hallucinogenic ngenxa yokuqokelelana kwe-neurotransmitter DMT. Ngamanye amaxesha isetyenziselwa ukuzonwabisa kule njongo xa ikhutshwe kwizityalo. Nangona kunjalo, ndicebisa ukuba kuthathwe amanyathelo okhuseleko afanelekileyo ukuphepha iziphumo ezibi. Soloko uqala ngedosi ephantsi kuqala.

Wenza ntoni uHarmaline?

Ngokusondeleyo ezinxulumene ne-harmine, i-harmaline yenye inhibitor ye-MAO efumaneka kwimbewu ye-Peganum harmala. Njenge-harmine, ithintela ukuwohloka kwe-monoamine neurotransmitters, ekhokelela kwiziphumo ezifanayo zengqondo kunye nomahluko othile.

Kwizifundo zokuthelekisa, i-harmaline iboniswa yomelele kancinci njenge-MAO inhibitor. Inobudlelwane obuninzi be-MAO-A ngaphezu kwe-MAO-B, iyenza ikhethe ngakumbi. Iziphumo ze-hallucinogenic ze-Harmaline zikhaba kwiidosi ezisezantsi ngenxa yokungena okuphezulu kwe-CNS.

Nangona kunjalo, i-harmaline iza netyhefu enkulu kunye neprofayili yomngcipheko, kubandakanya iziphumo ezinamandla ze-vasoconstrictive. I-alkaloids ye-Harmala inamandla kwaye ikhuselekile xa ilinganiswe kwimilinganiselo yazo yendalo, kunokuba ibe yodwa.

Ziziphi iimpembelelo zeHarmine kunye neHarmaline?

Xa isetyenziswe ngokuphakathi kwaye ilungiswe ngokufanelekileyo, iziphumo eziqhelekileyo ze-harmala alkaloids ezifana ne-harmine kunye ne-harmaline zinokubandakanya:

I-euphoria ephakathi, ukunyuka kweemvakalelo

Ukomelezwa kwengqondo, ukuzihlola

Ukunyusa ubuchule, inkuthazo

Ukonyusa amandla kunye nokukhuthaza

Ukuphucula ukuqonda kunye nokugxila

Lucid ukuphupha uphuculo

Kwiidosi eziphezulu, iziphumo ezinamandla ze-hallucinogenic zivela ezifana nezi:

Ukutshintsha koluvo lweemvakalelo

Ukuphazamiseka okubonakalayo, ukuphuculwa kombala

I-Synesthesia - ukudibanisa kweemvakalelo

Imibono efana nephupha kunye nemifanekiso

Amazwe angaqondakaliyo, ukupheliswa kwe-ego

Ezi zakhiwo ze-psychoactive zenze i-Peganum harmala umfundisi wezityalo ezingcwele kwizithethe ezininzi ze-shamanic zokuvumisa kunye nokuphilisa. Nangona kunjalo, njengakuyo nayiphi na into enamandla, ukuhlonipha izikhokelo zedosi efanelekileyo kunye nokuphepha ukusetyenziswa kakubi kwe-harmala kubalulekile.

Ziziphi iimpembelelo zeTi yeHarmala?

Indlela eqhelekileyo yokufunxa imbewu ye-Peganum harmala igalelwa ibe yiti. Iziphumo zeti ye-harmala zinokwahluka ngokusekelwe kwidosi esetyenzisiweyo ...

[Iqhubeka ngokunzulu inkcazo yeziphumo zeti ye-harmala, ukulungiswa, iidosi, izilumkiso zokhuseleko, njl.

Isishwankathelo, i-harmine, i-harmaline kunye namalungiselelo e-harmala anikezela uluhlu olubanzi lweziphumo ngokuxhomekeke kwizinto ezifana nedosi, i-biochemistry yomntu, kunye nokuba ezinye izinto zidityanisiwe. Xa isetyenziswe ngengqiqo kwaye imodareyitha, kukho ubungqina obuqinileyo beenzuzo zonyango ezinxulumene nempilo yengqondo, umsebenzi wokuqonda, ukukhula ngokomoya, kunye nokunye. Nangona kunjalo, ukusetyenziswa ngokungakhathali kunokukhokelela kwiziphumo ebezingalindelekanga ezibi.

Ziziphi iimpembelelo zeHarmine?

Ngelixa ubonisa isithembiso ngokwezonyango, i-harmala alkaloids kusafuneka iphathwe ngononophelo ukuthintela iziphumo ebezingalindelekanga:

Isicaphucaphu, ukugabha - Iidosi ezisezantsi ziyayinciphisa le nto

Ukungcangcazela, ukulungelelaniswa kwemoto

Ukudakumba kokuphefumla kumadosi aphezulu

Vasoconstriction, ukwanda koxinzelelo lwegazi

Ukuxhalaba, ukuphazamiseka

Ukungalali ngenxa yesiqingatha sobomi obude

Intloko ebuhlungu, ngakumbi xa i-comedowns

I-alkaloids ye-Harmala nayo ichasene namayeza athile, izinto, kunye neemeko zonyango. Okubaluleke kakhulu, akufuneki zidibaniswe ne-antidepressants ye-prescription ngenxa yomngcipheko we-serotonin syndrome. Abo bakumayeza engqondo kufuneka badibane nogqirha wabo phambi kokuba basebenzise iPeganum harmala.

Izilumkiso zokusetyenziswa ngokubanzi ziquka:

Qala ngeedosi ze-threshold ukuvavanya ukusabela

Sebenzisa izikali zemilligram ezichanekileyo zokulinganisa iidosi

Gwema ukudibanisa kunye ne-stimulants, i-psychedelics

Nikela ingqalelo ngokucokisekileyo ukuseta nokuseta

Yiba nabahleli bohambo ngeedosi eziphezulu

Hlala umanzi kwaye utyiswe ngexesha lokusetyenziswa

Musa ukusebenzisa oomatshini abanzima ngelixa unxilile

Ngelixa i-harmine kunye ne-alkaloids ehambelana nayo ibonisa isithembiso sokuphiliswa ngokwasemzimbeni nasengqondweni, ukusetyenziswa ngokungakhathali kuza neengozi njengayo nayiphi na ikhompawundi enamandla yengqondo. Kodwa xa ijongwa ngenyameko ize isetyenziswe ngenkathalo, amava e<em>harmala anokuba yingenelo kakhulu.

Isishwankathelo, i-harmine kunye nezinye i-alkaloids zinomdla wendalo mayeza ukuba inzululwazi isatyhila iindlela kunye nokusetyenziswa kwe. Ngophando olongezelelweyo kunye nokusetyenziswa ngobulumko, banokubonelela ngeenzuzo ezizodwa ze-psychopharmacological. Nangona kunjalo, ukwamkelwa kwezonyango okuqhelekileyo kuya kufuna izilingo ezininzi zeklinikhi ukumisela ulawulo olukhuselekileyo kunye nezikhokelo zokudosa ezisebenzayo.

Okwangoku, abo bakhetha ukuhlolisisa imiphumo ye-harmala bamele bathwale uxanduva olupheleleyo ngokuzifundisa ngokucokisekileyo baze bathabathe onke amanyathelo okhuseleko ayimfuneko. Qala ngokusezantsi kwaye unyuse iidosi ngelixa ujongisisa ukusabela. Kwaye xa ungathandabuzeki, qhagamshelana nogqirha wakho, isikhokelo se-shamanic, okanye umcebisi wokusetyenziswa kweziyobisi ukuze ubone ukuba i-harmala ifanelekile kwiimfuno zakho.