Njengengcaphephe ephambili kwinkalo, ndiza kwenza intsingiselo yesiqwenga sokwenziwa kwe-matrine, amacandelo omsebenzi, ukusetyenziswa, iimpembelelo kunye nombutho osemthethweni ngokujonga obona bungqina bubambekayo bamva nje.

Wenza ntoni umatrine?

Umbuzo yialkaloid efumaneka kwizityalo zohlobo lweSophora, ezifana nezinongo zaseTshayina I-Sophora flavescens. Kumayeza esintu aseTshayina, sele isetyenziswa ixesha elide ngokweempembelelo zawo zolungiso olubanzi. Uvavanyo lwangoku lutyhile i-matrine inemisebenzi emininzi yezamayeza, kubandakanya:

Ukunciphisa iintlungu kunye nokunciphisa

IAntiviral

Intsholongwane

Antifungal

Ukuqiniswa kweeseli kunye ne-anticancer

Immunomodulatory

IHepatoprotective

I-Cardiotonic

Amandla ayo okulwa nesifo, ukunciphisa ukucaphuka kunye nentuthumbo, ukukhusela isibindi, ukunceda isakhelo esingenakuchaphazeleka kunye nekhono lentliziyo lenze i-matrine isilungiso esidumileyo se-TCM. Isetyenziswa ngokubanzi kwiiresiphi zeemeko ezifana ne-hepatitis, isifo, i-arrhythmia, ukusuleleka kolusu kwaye sisiqalo nje eso.

Yintoni ukwakhiwa kwe-matrine?

Ukuthetha ngokwenziwa, matrine i-alkaloid eneresiphi yeatomic C15H24N2O. Igama layo le-IUPAC ngu (5S)- 5-methyl-1-azabicyclo [4.2.0] octan-2-enye. I-particle matrine iqulethe zombini i-quinolizidine ring kunye ne-pyridine indandatho ekwakhiweni kwayo kwe-bicyclic.

IMatrine yenye kuphela kwiialkaloids ezimbalwa ezinxulumeneyo ezifunyenwe kwizityalo zeSophora. Eminye imixube eguquguqukayo ibandakanya i-oxymatrine, i-sophocarpine, i-sophoramine, i-N-methylcytisine, cytisine, sophocarpidine, leachianone ukusuka apho, isibhakabhaka ngumda. Ingcambu iqulethe umxholo ophezulu kakhulu we-alkaloid.

Izicwangciso eziliqili zeemviwo zanamhlanje ezifana ne-HPLC ziyasivumela ukuba sihambise iincwadi ezingangxengwanga kakhulu imatrine isusa ukusetyenziswa konyango. Oku kuqinisekisa idosi echanekileyo, ekhuselekileyo xa ithelekiswa nolungiselelo lweziqholo...

Yintoni i-matrine insecticide?

Ngaphandle kweempawu zayo zonyango, i-matrine ikwahamba njengophawu lokutshiza kwebug. Incasa yayo erhabaxa ityhafisa iincukuthu ekubeni zixhamle kwizityalo. Umbuzo isebenza njengetyhefu yesisu ephembelela ubume obunxulumene nesisu seencukuthu. Uphando lubonisa ukuba iyanyanzela ngokuchasene nezinambuzane eziqhelekileyo zokuvuna ezifana neentwala, i-weevil kunye ne-beet armyworm ngaphandle kokwenzakalisa iincukuthu ezizuzayo njenge ladybugs.

Njengesitshabalalisi sezityalo eco-accommodating, isitshizi sezinambuzane ze-matrine sibonelela ngokhetho olukhuseleke ngakumbi ngokungafaniyo nolwakhiwo oluyinjineli lokulinywa kwendalo. Ifunyenwe kwiziseko ezisisiseko zesityalo seSophora, amagqabi kunye nembewu, imatrine Isitshizi sezinambuzane sinobungozi obuphantsi kwizilwanyana ezinomqolo kwaye sihlukana ngokukhawuleza emini. Ngokusetyenziswa okusemthethweni, inolawulo oluthile kwiibugs ngelixa inciphisa umphumo wendalo. Umbutho wam ubonelela ngesitshizi se-bug esekwe kwi-matrine eyaziwa kakhulu ngabavelisi.

Ithini inombolo ye-CAS ye-matrine?

Inombolo yelayibrari ye-CAS ye-matrine yi-519-02-8. Esi sichongi semathematika inoveli sivumela iingcali zefiziksi kunye neengcaphephe ukuba zibhekisele ngokuthe ngqo kwiathom ye-matrine kuwo wonke ubhalo olusengqiqweni kunye nokufayilishwa kwelungelo elilodwa lomenzi wechiza.

I-CAS imele i-Substance Edited compositions Administration, erekhoda i-synthetics eboniswe kwiilayisensi, amanqaku edayari kunye nokuhanjiswa okwahlukeneyo. Ukuzigcina kude nokungacaci, yonke into ithotywa inombolo ye-CAS. Ke kwi-matrine, i-519-02-8 ibhekisa ngokuthe gca kwikhompawundi yokwenziwa. Oku kuvumela imbalelwano echanekileyo ngaphandle kokungaqondani kuzo zonke iindawo zesayensi kunye nokutyhilwa kwamayeza.

Ngokufanelekileyo ibhekisa kwinombolo yeCAS ye imatrine iqinisekisa ukucaca okusengqiqweni ngelixa ivavanya uphando kwiipropati zayo zokubuyisela kunye nokusetyenziswa. Njengenkosi kule ntsimi, ndibhekisa ngokubanzi inombolo ye-CAS ye-matrine 519-02-8 kuqulunqo lwam olukhethekileyo kunye neelayisensi. Iphelisa nayiphi na imibuzo malunga nento ethile eboniswayo.

Isetyenziselwa ntoni i-matrine?

Ngembali ende yenjongo kumayeza aqhelekileyo aseTshayina, i-matrine inezicelo ezininzi eziluncedo. Nazi ezona njongo ziqhelekileyo ze-matrine kwimbono yobungqina bekliniki:

Unyango lwe-Hepatitis-Ukufakwa kweMatrine kunokuncedisa ekwehliseni iziphumo ebezingalindelekanga ze-hepatitis kunye nokunceda amandla esibindi kwi-hepatitis yentsholongwane eqhubekayo. Igxininisa kumboniso inokuthi ikuthintele ukuziphindaphinda kwe-HBV.

Ukuxhaswa kweSifo - iMatrine ibonisa ngokuchasene nokuzilolonga komhlaza kwizifundo zeeseli. Inokuthintela ukwanda kweeseli zesifo kwaye isebenze i-apoptosis. Isetyenziswe kufutshane nechemotherapy ukuphucula izibonelelo.

Usulelo lwesikhumba - Ulusu imatrine I-creams inokunyanga izifo zesikhumba ze-bacteria kunye ne-parasitic ngenxa yeempembelelo zayo ze-antimicrobial. Ukongeza, kunciphisa ukuqina kwesikhumba.

I-Arrhythmia - I-Matrine inokunceda ngokulawula izingqisho zentliziyo ngokuhamba njenge-blocker ye-potassium. Inceda i-arrhythmias ethile.

Isiqabu ekungonwabiseni - Iipropati zeMatrine eziqhelekileyo zokuthomalalisa iintlungu zithomalalisa intuthumbo enxulumene neenkqubo zonyango zesisu, iintanda, ukudumba kwamalungu kunye neemeko ezahlukeneyo.

Isikhokelo esingenakuchaphazeleka - Umbuzo ibhalansi yokungachukumiseki kunye nokubonakalisa ngokuchasene neempembelelo ezinobuzaza. Inokunceda ekunyangeni isifo sombefu, iintlungu zamalungu omzimba, i-psoriasis kunye nezinye iimeko ezitshisayo.

I-Matrine ukongezelela iphantsi kophononongo lokunceda iimeko ngokukhetha i-COPD, isifo seswekile, i-HIV, izigulo ze-neurodeergenerative kunye neengxaki zengqondo. Ngokuphonononga okongeziweyo, sihlala sityhila usetyenziso olutsha oluluncedo lwale khompawundi eguquguqukayo.

Ziziphi iimpembelelo ze-matrine?

Xa isetyenziswe ngokufanelekileyo, iimpembelelo eziqhelekileyo zokuthatha imatrine ungaquka:

Ukunciphisa ukucaphuka kunye nokuthuthumbisa

Yehlisa umkhuhlane

Umsebenzi we-Antimicrobial ngokuchasene ne-microorganisms, usulelo kunye nezinto eziphilayo

Ukhuseleko lwesibindi kunye nokuphuculwa kwesakhono

Ukubetha kwentliziyo okulinganayo

Isikhokelo esikhuselekileyo kunye nobutshaba kwintshukumo enovakalelo

Umqobo wophuhliso lomhlaza

Ukwenziwa kokuchama okwandisiweyo njenge-diuretic

Imilinganiselo ephezulu esetyenziswa eklinikhi inokuthi ngokunjalo inike iziphumo ebezingalindelekanga ezifana nokugula, ukubaleka, ukuqhawuka kunye nokuqhawuka kolusu kwizigulana ezithile. Ngokunjalo naso nasiphi na isiqholo sokubuyisela, kusisiseko ukugcina imithetho yedosi kwaye ujonge iimpendulo ezingathandekiyo.

Isishwankathelo, i-matrine yi-alkaloid ye-TCM entsonkothileyo enempembelelo enkulu ye-pharmacological. Inika ukuncitshiswa rhoqo kwintuthumbo, ukosuleleka, ukucaphuka, i-arrhythmias, ubuthathaka, ukugula kwesibindi kunye nokukhula kakubi. Nangona kunjalo, izigulana kufuneka zisebenzise i-matrine phantsi kolawulo lwengcali efundileyo ngenxa yeenkxalabo zobungozi obunokubakho kunye nonxibelelwano ngamachiza. Kwinqanaba xa isetyenziswa ngokufanelekileyo kufutshane namayeza anamhlanje, i-matrine ibonelela ngeenzuzo ezimangalisayo zokuchacha ezithathwe kubukrelekrele besityalo sakudala saseTshayina.