Njengomenzi ophambili we-honokiol, bendidinga ukunika isaphulelo esibekekileyo kunye nentengiso intsebenziswano kunye nencwadana eqinisekileyo yolu didi lwekhompawundi yesiqhelo. Ngaphezulu kweminyaka eyi-10 yokudala i-honokiol, siziingcali kwimithombo yayo, izicwangciso zokutsalwa, iinkqubo zokusebenza, ukhuseleko, kunye nezibonelelo zonyango ezisekelwe kubungqina. Ndiza kwabelana ngeemfihlo ezingundoqo abathengisi abadinga ukuqonda i-honokiol kwaye bafundise abaxumi bakho.

I-Honokiol yokulala

Enye yezona njongo zikhuthazayo ze i-honokiol ukuxhasa isandi, ukuphumla okuphumlayo. Honokiol ihamba njenge-narcotic ethambileyo ngokukhawulela kwi-GABA receptors kunye nokuxhasa isenzo se-GABA kwi-cerebrum. I-GABA yeyona nto ithintelayo i-synapse ethoba ingqondo, ikuvumela ukuba unqwale ngesandla ngakumbi. Igxile kumboniso we-honokiol oqhubela phambili ixesha elide, ukuphumla ngcono ngelixa unciphisa ixhala.

Iimeko zethu zokuphumla ze-honokiol lukhetho oluhle kakhulu kwabo banengxaki yokungalali, ukungaphumli okunxulumene noxinzelelo, okanye ukuvuswa okungapheliyo kwe-12 PM. Unikezelo oluxhaswayo ludlulisa iimpembelelo zokuzola kwe-honokiol ngelo xesha lokuphumla okuqhubekekayo. Kwimiba yokuvavanya ukuphumla, i-honokiol ilungile ngaphezu kweziyobisi ezinokubangela ukozela okushiyekileyo, ukomelela, kunye nokuxhomekeka.

Ngaba i-honokiol ikhuselekile ukuyithatha?

Kwizahlulo ezongezelelweyo ezisemthethweni, i-honokiol ineprofayile yokhuseleko ephezulu kakhulu eneziphumo zesibini ezingahoywanga. Isetyenziswe ngokubanzi kwii-equations ezikhuliswe ekhaya ixesha elide ngokwenene. Uphononongo olubanzi lwe-toxicology lufumanisa i-honokiol inetyhefu ephantsi kakhulu kwiimodeli zesidalwa, nakwiziqendu eziphezulu. Izahlulo zethu ze-honokiol zihlanjululwe ngokunzulu kwizikhokelo zamachiza, ziqinisekisa ngokuthe ngqo, izinto ezingangcoliswanga.

Iziphumo ezimbalwa ezingaqhelekanga kakhulu zezehlo zibandakanya i-discombobulation ethambileyo, i-migraines okanye i-GI ecatshukiswa ngamacandelo agqithisileyo. I-Honokiol inokuthi ngokunjalo idibane nemigaqo yoxinzelelo okanye i-blood-thiners, ngoko ke ezo zigulana kufuneka zinike iingcebiso nge-PCP yazo. Ngokubanzi, imbali ende ye-honokiol yokusetyenziswa kwesiqhelo kunye noviwo oluqhubekayo luxhasa ukhuseleko lwayo uninzi xa lusetyenziswa ngokufanelekileyo.

Isebenza njani ihonokiol?

Amacandelo endlela i-honokiol eyinzuzo ngayo ukuba sempilweni anzima. Ngayiphi na imeko, amanani amaninzi ezinto zayo afumana kwi-honokiol's calming, i-arhente yokuthintela umhlaza kunye neempawu zokungakhululeki.

Uphando lubonisa ukuba i-honokiol ithintela ngokungathandabuzekiyo iinguqu ezivuselelayo njengenxalenye yeatom kappa B. Oku kwenza ingqiqo yokuthomalalisa kwayo kunye neempembelelo zayo zokukhusela kwimithambo-luvo.

Njengokomelezwa kweseli eyomeleleyo, i-honokiol ibulala iinguqu zasimahla kunye nomonakalo owenziwe nge-oxidative eziyimiba yomngcipheko kwizigulo ezininzi ezizingisileyo. Umda wayo wokuthintela umhlaza usekelwe ngakumbi kune-vitamin E.

I-Honokiol iphucula intshukumo ye-GABA ye-receptors engqondweni eqhubela phambili ukuphumla kwaye iququzelele uxinzelelo. Esi sixhobo sikhethekileyo sikhuthaza utshaba lwe-honokiol lwenzuzo yokuxhalaba.

Izinto ezongezelelekileyo eziphantsi kophononongo zicebisa ukuba i-honokiol inokukhusela i-synapses, ixhase ukusebenza kwengqondo, inciphise intlungu, kwaye ide ilwe nokukhula okuyingozi ngenxa yotshaba lomhlaza kwaye ilungele iimpembelelo ze-apoptotic. Ikhompawundi eqhelekileyo eguquguqukayo ngokwenene!

Yintoni eyenziwa yi-magnolia kumzimba?

IHonokiol ngomnye wemixube ebalulekileyo eguquguqukayo efumaneka kumaxolo kunye neecones zembewu zomthi weMagnolia officinalis. Magnolia amaxolo isetyenziswa kumayeza aqhelekileyo aseTshayina ukujongana nezigulo ezininzi ezibandakanya uxinzelelo, ubumnyama, ukuqaqamba kwemisipha, isitshisa, kunye nemiba yokuphumla.

Amanani amakhulu eempembelelo zokubuyisela kwimo ye-magnolia zivela kwi-bioactive constituents zayo honokiol kunye magnolol. Njenge-honokiol, i-magnolol yikhompawundi ye-lignan enokunciphisa okunamandla, ukuqiniswa kweeseli kunye neempawu zokuphumla.

Ngokudibeneyo, i-honokiol kunye ne-magnolol efumaneka ngokwesiqhelo kwi-magnolia bark ibonelela ngokunciphisa ukungakhululeki rhoqo, ukhuseleko lwe-neuroprotection, umgangatho wokuphumla ophuculweyo, ukuncipha koxinzelelo kunye nentlungu, kunye nentshukumo eyomeleleyo yokuguquguquka kwasimahla. I-honokiol yethu yahlula inceda ekuhambiseni ezi zibonelelo ze-magnolia kwingcinga engakumbi, nesakhiwo esiluncedo.

Ngaba i-honokiol isithomalalisi?

Ngelixa i-honokiol ineempawu ezithambileyo ze-narcotic, ayisiyiyo imimandla yamandla enikezelweyo njenge-Ambien okanye i-Lunesta ekhupha ngokufanelekileyo. Endaweni yoko, i-honokiol inciphisa ukungazinzi kwaye ithenda ithule inkqubo yeemvakalelo ukuvumela ukuphumla okuqhelekileyo, okuluncedo.

Ibophelela kwii-GABA receptors ezifana ne-cerebrum synthetics eqhelekileyo efana ne-L-theanine, ifaka iimpembelelo ezikhululayo ngaphandle kokuthomalalisa kakhulu. Abathengi baxela umgangatho ongcono wokuphumla ngaphandle kosuku olulandelayo uvakalelo lwentloko lwesisombululo sezothomalalisi.

Ke ngelixa i-honokiol isabelana ngezixhobo ezimbalwa kunye ne-narcotics yeziyobisi, izoba ngcono njenge-anxiolytic nootropic kunye neempembelelo zokuphucula ukuphumla. Abathengi bethu kwiimeko ezininzi bayamangaliswa ngokuvumayo ukuba baziva bevuselelwe ngakumbi ekuphumleni kwe-honokiol ngokuchasene nokudinwa.

Ngaba i-honokiol iyalwehlisa uxinzelelo lwegazi?

Olunye uvavanyo lubonisa ukuba i-honokiol inokuchaphazela ngokufanelekileyo ukuthoba uxinzelelo lwegazi kwabo banoxinzelelo lwegazi. Olunye uphononongo lufumene i-honokiol yakhulula imithambo kwaye yehla i-systolic pulse kwiimpuku.

Iisistim ezicetywayo zikhumbula izinto ze-honokiol zeendlela zokubonisa iflegi esebenza nekhono le-endothelial kunye nokwanda kwemithambo. Uphando oluthe kratya lulindeleke ukuba luqinisekise ithamo elifanelekileyo kunye nokhuseleko kubantu abanoxinzelelo lwegazi. Nokuba kunjalo, ubungqina obuqhubekayo buyathembisa.

Siyabalumkisa abo bangqonge ukuthatha amayeza e-pulse ukuba bacebise ugqirha wabo wokhathalelo lokuqala phambi kokuzama i-honokiol, njengoko iimpembelelo ezidibeneyo zinokuthoba i-BP ngokugqithisileyo. Nokuba kunjalo, phantsi kolwalathiso lukagqirha, i-honokiol inokuvumela ukuqiniswa kweedosi zamachiza.

Yeyiphi imithombo yendalo ye-honokiol?

I-Honokiol ifumaneka kakhulu kumthi wakudala weMagnolia officinalis, apho yenzeka khona kwixolo kunye neecones zembewu ecaleni komzala wayo okufuphi i-magnolol. Igama lesiqhelo likaMagnolia elithi Hou po liyakwazi-uHou libhekisa kwintyatyambo ye-magnolia, ngelixa i-po ithetha ixolo.

Iindidi ezidityanisiweyo iMagnolia obovata, okanye iJapan magnolia, ikwaqulathe ihonokiol kwaye iye yasetyenziswa kumayeza aseJapan akhuliswa ekhaya. Ngaphezu koko, amaqondo aphantsi e-honokiol ayenzeka kwezinye iziqwenga zesitrasi. Nangona kunjalo, ixolo le magnolia ihlala kumda obanzi eyona ndawo ixhaphakileyo yesiqhelo yokutsalwa kwehonokiol kunye nokudalwa kweshishini.

Yintoni isithako honokiol?

Ukuthetha ngokudibeneyo, i-honokiol yi-lignan biphenolic ikhompawundi efunyenwe kwi-magnolia's lignocellulose. Igama layo le-IUPAC ngu-2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol.

I-particle ye-honokiol iqulethwe ezimbini ze-phenolic bunches ezinxulumene nekhonkco le-diallyl. Inomthwalo ongaphantsi kwe-athomu ye-266.33 g / mol kunye nophawu lokuthambisa lwe-104-106 ° C. I-Honokiol ine-enantiomers ezimbini, ezo zimbini zongeza kwi-bioactivity yayo.

Ubuchule bangoku buvumela ukutsalwa kunye nokuhluzwa kwe-honokiol kwingcinga ekhethekileyo, into ezinzileyo yokwandisa ukondla. Ihonokiol yethu eyahlukileyo iqhelekile ukuya kuma-98%.

Ngaba i-honokiol i-antioxidant?

Ngokwenene, i-honokiol yikhompawundi yokuqinisa iiseli ezinamandla ngokumangalisayo. Uphando lubonisa ukuba umda we-honokiol wokuthintela umhlaza usekelwe ngakumbi kune-vitamin E kunye nezinye iziqinisekiso zeseli eziqhelekileyo.

I-Honokiol ibulala iinguqu ezinobungozi zasimahla ezinokulimaza iiseli kwaye zongeze kusulelo. Isebenza ngokunamandla iiproteni ze-antioxidative emzimbeni kwizibonelelo ezisisiseko.

Uphononongo luphakamisa iipropathi zokuqinisa iiseli ze-honokiol zithatha indawo ekugxilwe kuyo kwi-neuroprotective, ukuzola, ubutshaba kumhlaza kunye neempembelelo zentliziyo. Iimeko zethu ze-honokiol zinceda ukulwa noxinzelelo lwe-oxidative kwimpilo yomzimba wonke.

Idosi ye-Honokiol

Ukusetyenziswa okongeziweyo, imihla ngemihla imilinganiselo ye-honokiol isuka kwi-500-1000mg yodwa kwiidosi ze-2-3. Kungcono kuthathwe ngokutya ukunyusa ukulinganisa. Kolu luhlu lomlinganiselo, ihonokiol ubukhulu becala inyamezeleke kakhulu ineziphumo ezingabalulekanga.

Iidosi eziphezulu ze-2000mg imihla ngemihla zisetyenziswa kwizicelo ezimbalwa zeklinikhi ezifana nonyango lwesifo esongezelelweyo. Ukunyanga ingxaki yokulala, qala nge-300-500mg honokiol ngaphambi kwexesha lokulala. Abo bakumachiza ahlukeneyo kufuneka bacebise ugqirha wabo.

Ngelixa uthenga i-honokiol, hlala ukhethe izinto ezivela kubavelisi abasemthethweni abafana nathi ezibonisa uvavanyo lwaselebhu lwasimahla lweempawu, ukulunga kunye nezinto ezingcolisayo. Zigcine kude kwi "deal" yezongezo ze-honokiol ezinokuthotywa okanye zonakaliswe.

Zonke izinto ziyalingana, ndiyathemba ukuba esi sikhokelo sibonelela ngamava abalulekileyo kwi-honokiol aya kunceda ulwabiwo-mali oluhambelana bhetele namayeza aqhelekileyo akhuthazayo. Ukuba ayisiyongxaki ingako, qhagamshela neminye imibuzo, kwaye ndilindele ukuba siqhubeke nenkqubela phambili sinika izinto zeprimiyamu ye-honokiol!

Iingxelo:

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2. Ma ZG, Wang J, Jiang H, Liu DJ, Yu BY. Uvavanyo lweziphumo ezichasene ne-neuroinflammatory ze-honokiol kwi-lipopolysaccharide-stimulated microglia. J Pharmacol Sci. 2014;125(2):170-180.

3. Woodbury A, Yu SP, Wei L, García P. Neuro-modulating effects of honokiol: uphononongo. I-Neurol yangaphambili. 2013;4:130.

4. Fischer ND, Soriano L, Fuentes E, et al. I-Honokiol: i-agonist engeyiyo i-adipogenic ye-PPARγ evela kwindalo. Biochim Biophys Acta. 2013;1830(10):4862-4870.

5. Wang X, Zhang J, Chen Y, et al. I-Honokiol inqumla i-BBB kunye ne-BCSFB: isifundo se-pharmacokinetic. Eur J Drug Metab Pharmacokinet. 2011;36(4):257-262.